We are working to develop novel methods for controlled delivery of bioactive agents
The Ghandehari Lab focuses on new approaches for controlled drug delivery and better understanding of nanoparticle structural features that result in toxicity.
Current projects in our lab include design of recombinant polymers for localized drug delivery and as liquid embolics, establishing a correlation between physicochemical properties of silica nanoparticles and their downstream immune adverse effects, development of lipid-based nanostructures for mRNA delivery, drug delivery approaches for more effective and less toxic treatment of chronic rhinosinusitis, drug modification strategies to reduce adsorption to extracorporeal membrane oxygenation systems, water-soluble polymer-collagen mimetic peptide conjugates for targeting tumor extracellular matrix, and imaging agent delivery for improving surgical outcomes in oropharyngeal squamous cell carcinoma.
The lab is led by Hamid Ghandehari, professor and chair of Molecular Pharmaceutics, professor of Biomedical Engineering, and director of the Utah Center for Nanomedicine.